Low Temperature Chemical Synthesis of Three Dimensional Hierarchical Ni(OH)2-Coated Ni Microflowers for High Performance Enzyme-Free Glucose Sensor
Arumugam Manikandan1*, Vediyappan Veeramani2, Shen-Ming Chen2, Rajesh Madhu2, Ling Lee1, Henry Medina1, Chia-Wei Chen2, Yu-Lun Chueh1
1Department of Materials Science & Engineering, National Tsing-Hua University, Hsinchu City, Taiwan
2Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan
* presenting author:Manikandan Arumugam, email:mani111nano@gmail.com
Since prevention methods of type-II diabetes and knowledge of prediabetes are lacking, the development of sensitive and accurate glucose sensors with an ultralow detection limit is imperative. In this work, the enzyme-free glucose sensor based on three dimensional (3D) hierarchical Ni microflowers with a Ni(OH)2 coating layer has been demonstrated in a simple one-step chemical reaction at a low temperature of 80 oC. The as-synthesized materials were characterized by several analytical and spectroscopic techniques. In addition, thin Ni(OH)2 layer formed at the surface of Ni microflower was evidenced by RAMAN, HRTEM and XPS, which is the key factor to achieve high sensitive enzyme-free glucose sensors based on low-cost materials such as copper, nickel and their oxide and hydroxide. Moreover, our modified electrode exhibits an outstanding detection limit as low as 2.4 nM with an ultra-high sensitivity of 2392 µA mM−1cm−2, which is attributed to not only the increased surface area due to the controlled formation of spikes but also the contribution of Ni(OH)2 coating layer.

Keywords: Non-enyzmatic glucose sensor, Ni microflower, Hydroxide, High sensitive, Diabetes