Modeling Cell Crawling on a Substrate: Mode Expansion and Symmetry
Hsuan-Yi Chen1,2*
1Department of Physics, National Central University, Taoyuan, Taiwan
2Institute of Physics, Academia Sinica, Taipei, Taiwan
* presenting author:Hsuan-Yi Chen, email:hschen@phy.ncu.edu.tw
Cell crawling on a substrate is a complex system problem where chemical and mechanical components are strongly coupled. Naively one may think that cell crawling behavior can be understood only when all these components are included. In this talk I will present a few interesting experimental observations and theoretical models that suggest simple views actually can help us to gain deeper insight for this seemingly complicated process. First I will discuss the moment expansion of traction stress for a rest cell and a moving cell, such comparison helps us to view a moving cell as a kind of active soft matter. Then I will talk about the relation between shape and motion, especially how rotation state of a cell might be related to the symmetry and nonlinear coupling between cell shape and myosin distribution inside the cell. This example helps us to see how cell movement can be viewed as a low-dimensional nonlinear dynamical system.


Keywords: cell movement, active soft matters, biophysics